The biggest question I know of has to do with evolution. At what scale is evolution currently happening? The two basic approaches I have for dealing with this are: What we’re seeing is what’s happening. This is the first big bang and everything we see is what it is.
The other approach is way more interesting. That this is not the first big bang, and this is just one step on the road. Countless things all evolve in parallel.
Evolution finds ‘set points’. An example of a set point is the laws that matter operate by. Certain constants exist in the universe, like how strong gravity is. That’s an example of a physical set point, another one might be the Internet. Certain things are inevitable given the right environment, and self-direction tends to make everything trend towards those environments.
What, exactly, is the scale that evolution currently acts on? An answer to this question would affect literally everything. Whether things like souls exist and what their nature is.