Is there any case where using a front end JavaScript framework or library with Node.js/Express is not preferable?

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The big one I can think of is when the size of your payloads is super-critical and highly constrained. There are lightweight versions of many popular libraries and frameworks. If you like jQuery, there’s jquery-lite. If you like Underscore, there’s lo-dash. If you like React, there’s Mithril.js. If yo