What is the best way to ask for help from the divine or the creator or the universe when you have a hard situation in life after trying everything that a human can do?

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Ask for clarity, not for help. The same advice goes for God as with people, ask for help, and receive advice, ask for advice, and receive help. God’s going to be way more inclined to throw you a bone if He can see you’re really interested in not letting it happen again.